Thermodynamics of triiodothyronine nuclear receptor interaction. Role of hydrophobicity in triiodothyronine binding to its receptor.
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چکیده
منابع مشابه
Thermodynamics of triiodothyronine nuclear receptor interaction. Role of hydrophobicity in triiodothyronine binding to its receptor.
We have investigated the thermodynamic properties of triiodothyronine (T3)-solubilized hepatic nuclear receptor interaction. These studies revealed that the equilibrium constant was markedly dependent on temperature and van't Hoff plots revealed a significant deviation from linearity. Both enthalpy and entropy changes decreased with increasing temperature such that at 37 degrees C both were neg...
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This work was presented in part at the 53rd Annual Meeting of The American Thyroid Association, Cleveland, Ohio, 7-10 September 1977. Dr. Larsen is an Investigator of the Howard Hughes Medical Institute. Received for publication 29 August 1977 and in revised form 11 January 1978. well with both the change in TSH and the nuclear occupancy, suggesting a linear relationship between the integrated ...
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Nuclei were prepared by sucrose sedimentation of liver homogenates from rats given (125)I-labeled triiodothyronine in vivo. The nuclear extract obtained by treatment of the nuclear pellet with 0.4 M KCl contains the [(125)I]triiodothyronine that had been injected in vivo bound to protein(s). The triiodothyronine bound to nuclear protein(s) in vivo does not readily exchange with triiodothyronine...
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15 صفحه اولPhysiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary.
Our recent in vivo studies have suggested that intrapituitary l-thyroxine (T(4)) to 3,5,3'-triiodo-l-thyronine (T(3)) conversion with subsequent nuclear binding of T(3) is an important pathway by which circulating T(4) can inhibit thyrotropin release. The present studies were performed to evaluate various physiological and pharmacological influences on these two processes in rat anterior pituit...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1982
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)68202-5